Diets of Holstein replacement heifers in scaled farm was optimized by CPM model, and the effects of optimized diets on growth, development and blood biochemical parameters were evaluated in this study. For-ty Holstein replacement heifers with the same months of age ( 7 months of age) , and similar body height and weight were randomly divided into control and test groups according to paired experimental design, and each group had 20 heifers. Heifers of control group were fed original diets of the farm, while those of test group were fed diets optimized by CPM model. The experimental period was 270 days. The results showed as fol-lows: replacement heifers fed optimized diets had significantly higher cannon circumference at 8, 10, 11, 13 and 15 months of age ( P<0.01);serum calcium content of replacement heifers fed optimized diets was signifi-cantly higher than that of heifers fed original diets ( P<0.05);cost of optimized diets of 7 months of age, 8 to 9 months of age, 10 to 12 months of age, 13 to 15 months of age was decreased by 1. 02, 0.78, 0.62 and 0.52￥/(head·d) than that of original diets, respectively. In conclusion, diets optimized by CPM model can increase cannon circumference of Holstein replacement heifers, improve growth and absorption of blood calci-um, and decrease feeding cost;CPM model can be used to evaluate and optimize diets formulation of Holstein replacement heifers.%本文利用CPM模型优化规模化奶牛场7～15月龄后备母牛饲粮，研究优化后饲粮对后备母牛生长发育和血液生化指标的影响。选用相同月龄（7月龄），胎次、体高和体重相近的健康后备荷斯坦母牛40头，按照配对试验设计把试验奶牛随机分为2组，每组20头，对照组采用奶牛场现有的饲粮配方，试验组采用 CPM模型优化后的饲粮配方。试验期为270 d。结果表明：饲喂CPM模型优化饲粮极显著提高了后备母牛8、10、11、13和15月龄的管围（ P＜0．01）；试验组后备母牛血清中钙含量在8月龄时显著高于对照组（ P＜0．05）；优化后7月龄、8～9月龄、10～12月龄、13～15月龄饲粮成本比调整前分别降低了1．02、0．78、0．62和0．52元/（头·d）。由此可见，饲喂CPM模型优化饲粮可提高后备母牛的管围，促进后备母牛的生长，促进血钙的吸收，降低饲养成本，CPM模型可用于评价和优化后备荷斯坦母牛的饲粮配方。
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