寄生虫烯醇化酶的研究进展

摘要

烯醇化酶是糖酵解过程中促进磷酸甘油酸和磷酸烯醇式丙酮酸相互转换的重要催化酶，同时也是存在于真核和原核细胞表面的多功能酶。最近研究发现，它能够激活纤溶酶原，参与病原的感染过程，而且也是主要的免疫刺激性蛋白和药物作用靶点。本文综述当前寄生虫烯醇化酶的研究成果，旨在探讨其作为寄生虫病的诊断、潜在候选疫苗及药物靶点的可能性。%Enolase, an important glycolytic enzyme that catalyses the conversion of phosphoglycerate to phosphoenolpyruvate, was identi-fied as a multifunctional protein on the surface of most eukaryotic and prokaryotic cells. Recent studies have revealed that this enzyme could activate the plasminogen,involving in the processes of parasite infection. It is also considered to be a major immunostimulatory protein and drug target. This paper reviews the current research results in parasite enolase, and explores its potential for diagnosis, vaccine candidate and drug targets of parasitic diseases.