Objective To investigate the influence of different antihypertensive medication on erectile function in middle-aged and elderly hypertensive men. Methods Total of 244 married out-patients with essential hypertension, age range was between 40 to 70 years, who received medication, were enrolled in the study. Self -Grading of ED was evaluated by using the IIEF-5 questionnaire. Results For all patients, 28.28% of them had normally erectile function, and 71.7% had various degrees of erectile dysfunction including 49.18% mild ED, 6.56% moderate ED and 15.98% severe ED. The IIEF-5 score of patients treated with β -blockers was lower than that patients untreated with β -blockers(P<0.01). Furthermore the incidence of erectile dysfunction of patients treated with P -blockers was higher than that of patients untreated with β -blockers (P<0.05). There were no significant differences in erectile dysfunction among patients with different antihypertensive medication such as diuretics, angiotensin converting enzyme-inhibitors, calcium channel blockers and angiotensin Ⅱ receptor antagonists. Conclusion β -blockers might contribute to incidence of erectile dysfunction in hypertensive patients, and other antihypertensives medication showed similar influence on incidence of erectile dysfunction.%目的 探讨不同抗高血压药物对于男性勃起功能的影响.方法 问卷调查2008年10月至2008年12月来我院就诊的已婚男性、原发性高血压患者244例,年龄40～70岁.记录服用的抗高血压药物并应用国际勃起功能指数-5(IIEF-5)评估其勃起功能.结果 244例高血压患者勃起功能正常者69例(28.28%),勃起功能障碍(ED)者175例(71.72%).其中轻度障碍者120例(49.1 8%),中度障碍者16例(6.56%),重度障碍者39例(15.98%).β受体滞剂组IIEF分值低于非β受体阻滞剂组,ED发生率高于非β受体阻滞剂组,其他药物组如血管紧张素转换酶抑制剂组、血管紧张素Ⅱ受体拮抗剂组、钙离子拮抗剂组、利尿剂组间差异均无统计学意义.结论 高血压患者中ED的发生率较高(175/244,71.72%), 服用β受体阻滞剂对患者勃起功能有不利影响,而其他药物对于勃起功能影响相似.
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