控制良好的糖尿病仍是老年男性下尿路症状的危险因素

摘要

Objective To investigate whether diabetes with good glucose control is the risk factor for lower urinary tract symptoms in elderly males or not. Methods 172 patients with age≥60 were enrolled in our study, including 52 patients with diabetes and HbA1C<7%, and 120 patients without diabetes. All the patients were required for IPSS, storage and voiding score, history of incontinence, examination of prostate ultrasound and serum PSA level.statistical analysis, including t test, spearman analysis and regression analysis, was used for comparison between two groups and the correlation between diabetes and lower urinary tract symptoms. Results IPSS, storage and voiding score, history of incontinence in the group with diabetes were significantly higher than the group without diabetes (P<0.05). Years with diabetes were significantly correlated with IPSS, storage and voiding score (P<0.05). The risk factor for lower urinary tract symptoms were both diabetes with good glucose control (OR 1.77) and years of diabetes (OR 1.098). Conclusion No matter whether diabetes patients have good or bad glucose control, diabetes is still the risk factor for lower urinary tract symptoms. Lower urinary tract symptoms will be more severe with progression of diabetes.%目的：探讨血糖控制良好的糖尿病是否仍然是老年男性下尿路症状（LUTS）的危险因素之一。方法收集172例年龄≥60岁参与我院体检的老年男性的国际前列腺症状（IPSS）评分，潴尿期（storage）评分，排尿期（voiding）评分，急迫性尿失禁病史，经直肠前列腺超声（TRUS）以及前列腺特异性抗原（PSA）的资料，将患者分为两组，糖尿病控制稳定组52例，糖化血红蛋白（HbAlc）均＜7%，非糖尿病组120例。比较两组患者各指标是否有差异，并计算糖尿病与LUTS的相关性，并做回归分析。结果糖尿病控制稳定组患者的IPSS评分，storage评分，voiding评分及急迫性尿失禁发生率均显著高于非糖尿病组患者（P均＜0.05）。糖尿病患者患病病程与IPSS评分，storage评分及voiding评分均呈显著相关性（P均＜0.05）。糖尿病本身及糖尿病患病病程均为LUTS的危险因素（OR值分别为1.772及1.098，P均＜0.05）。结论糖尿病即使血糖控制良好，仍是老年男性LUTS的危险因素，并随着患病病程的增加，症状的严重程度逐渐升高。