Osteosarcoma(OS)is one of the most difficult cancers to treat due to its resistance to chemotherapy.The essential role played by Mel-l in promoting chemoresistance has been observed in a variety of cancers,including OS,while the underlying mechanism remains unclear.We investigated the expression of Mcl-1 in 42 paired OS specimens obtained before and after adjuvant chemotherapy,and its correlation with clinicopathological characteristics.Loss and gain of function studies were performed to analyze the effects of Mcl-1 modulations on the chemosensitivity,and the mechanism involved in the deregulation of Mcl-1 in OS cells.
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