以盐酸克伦特罗为模板分子,采用沉淀聚合法合成了克伦特罗的分子印迹聚合物,并以其为离子载体,制得分子印迹聚合物膜克伦特罗离子选择性电极.在最优实验条件下,电极对克伦特罗阳离子的检出限可达7.0×10-8mol/L,线性范围为1.0×10 7～1.0×10-4 mol/L,能斯特斜率为55.7 mV/decade.此电极具有优越的选择性、快速的响应时间以及良好的稳定性；已成功应用于实际猪尿样品中克伦特罗的测定,加标回收率为98％～107％,检测时间小于3 min.%A polymeric membrane ion-selective electrode for the determination of clenbuterol is described. It is based on a molecularly imprinted polymer (MIP) as an ionophore for molecular recognition, which can be synthesized by precipitation polymerization using clenbuterol hydrochloride as a template molecule. Under the optimized conditions, the proposed membrane electrode exhibits Nernstian response to the protonated clenbuterol over the concentration range of 1. 0 X 10-7-1. 0× 10-4 mol/L with a slope of 55. 7 mV/decade, and the detection limit is 7. 0×10-8 mol/L. The MIPbased sensor shows excellent selectivity, rapid response time and satisfactory long-term stability. The potentiometric sensor has been successfully applied to determine the clenbuterol in pig urine samples with recoveries between 98% and 107% and an analytical time of less than 3 min.
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