纳米孔分析方法在有毒物质检测中的应用

摘要

As a novel analytical method, nanopore sensing is widely applied in many fields such as nucleic acids sequencing, protein / peptide analysis, detection of metal ions and biomacromolecules including virus, bacteria, etc. With the growing public concerns over dietary safety and public security, there has been a greater demand on the detection of toxic molecules. With its high sensitivity and selectivity, nanopore sensing is considered as a more powerful assay, which has been reported in many research articles. Accordingly, this paper surveys the application studies of nanopore sensing in detection of toxic molecules.%纳米孔技术作为一种新型的分析检测方法,被广泛应用于核酸测序、蛋白质/多肽分析以及病毒、微生物等生物大分子和金属离子的检测.随着人们对公共安全和食品药品安全等问题的日益关注,对有毒物质的检测也提出了更高的要求.鉴于纳米孔分析方法具有高灵敏度和高选择性等优点,很多研究团队将其应用于有毒物质的检测,进行了很多的研究工作.本文针对近年来纳米孔技术在有毒物质检测中的应用进行综述,并对其应用前景进行了展望.