滤泡辅助性T细胞与自身免疫性疾病

摘要

滤泡辅助性T细胞（ follicular helper T cells， Tfh）是一类主要定位于B淋巴细胞滤泡形成生发中心的特殊CD4＋T细胞亚群，它在诱导B细胞活化、分化、产生抗体的各个环节均发挥着重要的辅助功能。 Tfh细胞在机体内的正常表达有利于维持机体正常的免疫应答和内环境的稳定，一旦其表达和（或）功能出现异常，则会引起体内抗体异常表达，从而导致自身免疫性疾病的发生。认识和研究Tfh细胞在自身免疫性疾病中可能的发病机制及其功能有利于临床上更好地认识疾病，为疾病的治疗提供新的思路。%Follicular helper T ( Tfh ) cells are the specialized CD4 +T cell subsets, which mainly reside in the germinal center ( GC) .Tfh cells play critical“helper” function in the process of activation and differentiation of B cells, and producing immunoglobulin.Normal expression of Tfh cells in human is essential for maintaining the normal immune response, as well as the stability of homestasis.Abnormal expression and/or dysfunction of Tfh cells are involved in the development of autoimmune diseases, which would result in the abnormal expression of antibodies.Therefore, an understanding and research of the appropriate mechanism and function of Tfh cells in these autoimmune diseases may help us better understand these diseases, which might provide good insights into disease therapy.