细菌纤维素对兔耳增生性瘢痕中羟脯氨酸含量的影响

摘要

目的:观察细菌纤维素(BC)对兔耳增生性瘢痕的影响.方法:成年新西兰白兔30只,全麻下建立兔耳腹侧增生性瘢痕模型.在术后第21天(创面上皮化)后,根据每只兔耳5个不同瘢痕面随机给予不同处理方式分为5组,分别为3组实验组(贴敷持水性不同的细菌纤维素(BC)膜,A组BC(1:5),B组BC(1:6)、C组BC(1:8))和2组对照组(贴敷疤痕贴的为阳性对照D组,未贴任何敷料且瘢痕自然生长的为阴性对照E组).在给予瘢痕面不同处理方式之后的第0天、第14天、第21天、第28天、第42天、第56天分别切取标本行羟脯氨酸(Hpr)含量检测.结果:A、B、C三组瘢痕Hpr含量高于D组但低于E组(P＜0.01);A、B、C、三组瘢痕Hpr含量分别比较A>B>C组(P＜0.05).结论:兔耳创面愈合后增生性瘢痕贴敷的细菌纤维素抑制了兔耳瘢痕的增生,各组细菌纤维素减轻增生性瘢痕效果比较A组＜B组＜C组.%Objective To observe the effects of Bacterial Cellulose (BC) on reducing rabbit ears hypertrophic scar.Methods Hypertrophic scar model were established on 30 adult New Zealand rabbit ears with general anesthesia after the 21th days postoperative (Wound epithelization),five different scars of each rabbit ear which were given different treatments were randomly divided into 5 groups. Including three experimental groups (patching different absorbent bacterial cellulose (BC)film such as the BC(1:5) treated-group(Group A),the BC(1:6) treated-group(Group B),the BC(1:8) treated-group (Group C)) and two control groups (patching silicone scar patch as a positive control group D、without sticking any litterand natural growth of scar as a negative control group E). After 0 d、14d 、21d、28d、42d、56d of givening scar surface different treatments, making hydroxyproline (Hpr) content detection. Results The Hpr contents in group A、B、C were more than in group D but lower than in group E.Compared the content of Hpr in group A、B、C,A＞B＞C (P＜0.05). Conclusion Bacterial cellulose inhibit the rabbit ears hyperplastic scar.compared the effection of each groups bacterial cellulose. A＜B＜C.