巨细胞修复性肉芽肿的诊疗分析及文献复习

摘要

Objective To investigate the clinicopathological features, diagnosis and treatment of giant cell granuloma. Methods The clinical and pathological datas of 3 cases in maxillary bone, temporal bone and maxillary sinus were analyzed retrospectively.The relevant literatures were also reviewed. Results The patients presented with local painless mass, part of which were aggressive. Histopathological feature was,replacement of the normal bone structure with proliferating fibrous tissue containing numerous giant cells was shown. Conclusion Giant cell granuloma was a non-neoplastic lesion,and extremely rare.lt was somewhat difficult to make a correct diagnosis.Combining the clinical data and pathological feature were more helpful to the diagnosis.Total surgical resection was an effective therapeutic method.%目的:探讨巨细胞修复性肉芽肿的临床病理特征、诊断与治疗.方法:对3例巨细胞修复性肉芽肿患者(分别位于上颌骨、颞骨和上颌窦)的临床病理资料进行回顾性分析,并复习相关文献.结果:巨细胞修复性肉芽肿临床表现为局限性无痛性肿块,有时具有侵袭性.组织病理学特征为骨组织被纤维组织代替,多核巨细胞呈散在或灶性分布于纤维基质中.结论:巨细胞修复性肉芽肿是一种非肿瘤性病变,临床极为罕见,诊断有一定困难,需要结合临床和病理进行分析,彻底切除病变是有效的治疗方法.