目的:观察羟基乙酸联合1319nmNd:YAG激光治疗面部皱纹的效果并探讨其除皱机制.方法:30例患者,随机分为两组,A组子果酸治疗组,B组为联合治疗组,子果酸联合1319nmNd:YAG激光治疗；选择40只SD大鼠,随机分空白对照 组,光老化组,果酸治疗组及联合治疗组各10只,联合治疗组子果酸联合1319nmNd:YAG激光治疗并比较不同组大鼠皮肤组织学 改变.结果:联合治疗组有效率达80％,而果酸治疗组达60％.组间有效率比较,差异具有统计学意义(x2=3.801,P＜0.05)； 联合治疗组高于果酸治疗组.造模光老化大鼠真皮胶原变性、断裂、减少、排列紊乱,经激光及果酸治疗后得到改善,联合治疗 改善更明显.结论:1319nmNd:YAG激光联合羟基乙酸面部除皱疗效优于单纯羟基乙酸治疗.%Objective To investigate the effectiveness of glycolicacid and 1319nm Nd:YAG laser in wrinkle reduction of face and explore its possible mechanism. Methods 30 patients were divided into two groups randomly. Group A was given only glycolicacid treatment, group B was treated with glycolicacid and 1319nmNd:YAG laser. At the same time 40 SD -rats were randomly divided into control group, photoaged group.glycolicacid treatment group and laser -glycolicacid treatment groupjaser-glycolicacid treatment group was treated by 1319nmNd:YAG laser and glycolicacid. Results The effectiveness ratio of two groups were 80.0%, 60.0% respectively, and there was a significantly statistic difference between them. (^ =3.801, P<0.05).And the degeneration/eduction and disorder of dremal collagenimproved after 1319nm-Nd:YAG laser and glycolicacid treatment, laser- glycolicacid treatment gr- oup was better in effect than glycolicacid treatment group. Conclusion 1319nm Nd: YAG laser comebined with glycolicacid had been proven to be better for wrinkle reduction in face.
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