新疆地区口腔颌面部淋巴瘤患者EBV感染与临床病理特征的相关性分析

摘要

目的：通过检测口腔颌面部淋巴瘤患者的EBV水平，分析其与临床病理特征之间的相关性。方法：选取2014年1月1日至2015年1月1日在新疆医科大学第一附属医院收住的口腔颌面部淋巴瘤患者，采用ISH技术检测EBV的水平，从性别、年龄、肿瘤部位、HL淋巴结内外、病灶数量、临床分期、肿瘤分型、病理类型、LDH水平等方面分析其相关性。结果：ISH技术检测EBV感染阳性者占45%。与性别、年龄、肿瘤部位、病灶数量无关(P＞0.05)；与HL淋巴结内外发生部位(结内60%，结外25%，P=0.012)、临床分期(I+II：30.8%, III+IV：71.4%,P=0.023)、肿瘤分型(NHL：54.9%，HL：11.1%,P=0.017)、病理类型(NKT：84.6%，BCL：23.1%，TCL：20%, HL：11.2%,P=0.034)、LDH水平(LDH＞250mmol/l：60%, LDH≤250mmol/l：36%, P=0.026)有关(P＜0.05)；HL淋巴结内外发生部位、临床分期、肿瘤分型、病理类型、LDH水平均是颌面部淋巴瘤患者EBV感染的独立危险因素(P＜0.05)。结论：EBV感染在口腔颌面部淋巴瘤患者呈高度阳性表达，HL淋巴结内外发生部位、临床分期、肿瘤分型、病理类型、LDH水平均是颌面部淋巴瘤患者EBV感染的独立危险因素。%ObjectiveTo detect the level of EBV in patients with oral and maxillofacial lymphoma and analyze the correlation between level of EBV and the clinicopathological characteristics.Methods Select patients with oral and maxillofacial lymphoma at the First Affiliated Hospital of Xinjiang Medical University from January 1,2014 to January 1,2015,ISH was used to detect the level of EBV in these patients. The correlation was analyzed from sex, age, tumor location, HL lymph nodes, clinical stage, tumor type,pathological type and LDH level.ResultsThe positive expression of ISH was 45% in EBV infection. And sex, age, tumor location, the number of lesions was not related with the result (P>0.05). While the result was related with some aspects of the occuring cite of the internal and external of HL lymph nodes (node within 60%, 25%,P=0.012) and clinical staging (I+II:30.8%, III+IV:71.4%,P=0.023), tumor type (NHL:54.9%, HL:11.1%,P=0.017), pathological type (NKT:84.6%, BCL:23.1%, TCL:20%, HL:11.2%,P=0.034), LDH (lactate dehydrogenase (LDH) > 250mmol/l:60%, LDH is less than or equal to 250mmol/l:36%,P = 0.026) (P<0.05); HL lymph node and tumor staging, clinical stage, pathological type, LDH level were independent risk factors of EBV infection in patients with maxillofacial lymphoma (P<0.05).Conclusion EBV infection in oral and maxillofacial lymphoma patients was highly positive expression, HL lymph nodes and the clinical stage, clinical stage,tumor classiifcation, pathological type, LDH level are the independent risk factors of EBV infection in patients with maxillofacial lymphoma.