Objective To investigate the effect of VSD technique combined with epidermal growth factor solution on wound healing and inflammatory response in patients with deep burn. Methods 100 patients with deep burn in our hospital from February 2010 to February 2017, were divided into control group and treatment group according to the random number method, 50 cases in each group. After wound cleaning, the two groups of patient's wound was closed with VSD device, the treatment group was treated with epidermal growth factor solution washing suction device and the wound of the patients, the control group was treated with normal saline. The wound healing condition and the inflammatory reaction conditions were compared between the two groups. Results After treatment 5 days, there was no significant difference between the two groups wound healing rate (P>0.05), but compared with the control group, inflammatory markers interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-α), as well as stress indicators noradrenaline (NE), epinephrine (E), plasma renin activity (R) of treatment group were significantly decreased (P<0.01). The wound healing rates of 10 d and 15 d were significantly increased in the two groups, and the treatment group was higher than that in the control group (P<0.05). In the treatment group, the wound healing time, the number of scar healing cases and the number of infected patients were significantly lower than the control group (P<0.05). Conclusion VSD technology combined with epidermal growth factor solution can promote the wound healing of deep burn patients, improve the treatment effect of the wound, reduce the patient's inflammatory stress reaction. It is worthy of clinical promotion.%目的:探讨负压封闭引流(VSD)技术结合表皮生长因子溶液对深度烧伤患者创面愈合及炎症应激反应的影响.方法:选取本院2010年2月-2017年2月收治的100例Ⅱ度烧伤患者为研究对象,按照随机数字法分为对照组和治疗组,每组50例.两组患者创面清洗完成后,采用VSD装置对创面进行封闭,对照组采用生理盐水冲洗,治疗组采用表皮生长因子溶液冲洗.比较两组患者的创面愈合情况和炎症应激反应情况.结果:治疗5d后,两组创面愈合率差异无统计学意义(P>0.05),但与对照组相比,治疗组的炎症指标白介素-1(IL-1)和肿瘤坏死因子-α(TNF-α),以及应激指标去甲肾上腺素(NE)、肾上腺素(E)、肾素(R)均显著降低(P<0.01);治疗10d、15d后两组创面愈合率均显著升高,且治疗组高于对照组(P<0.05);治疗组创面愈合时间、瘢痕愈合例数及感染例数与对照组相比,均显著降低(P<0.05).结论:VSD技术结合表皮生长因子溶液能促进深度烧伤患者的创面愈合,提高创面治疗效果,减轻患者的炎症应激反应.
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