最近十年对细胞生物材料的研究已经转向三维研究.通过3D细胞培养模拟天然细胞外环境,水凝胶提供了良好的3D生物材料组织支架.因此,明胶甲基丙烯酰(Gelatin methacryloyl,GelMA)水凝胶最近受到越来越多的关注.这主要由明胶的固有生物活性和可光交联水凝胶的优点.各种研究表明GelMA是一种多功能基质,可用于从血管系统到软骨和骨工程组织的类似物.生物支架和生物培养方法的结合对于证明细胞功能或构建形状保持至再生组织的发展是很必要的.GelMA在该过程中具有关键的指导作用,并且有利于加快临床相关应用的发展.%In the last decade, research on cell biomaterials has shifted to three-dimensional research. By modeling the natural cell extracellular environment by 3D cell culture,the hydrogel provides a good 3D biomaterial tissue scaffold. Therefore,Gelatin methacryloyl (GelMA) hydrogels have attracted more and more attention. This is mainly due to the inherent bioactivity of gelatin and the advantages of photo-crosslinkable hydrogels. Various studies have shown that GelMA is a multifunctional matrix that can be used from vascular systems to cartilage and bone engineering tissue analogues. The combination of biological scaffolds and biocompatible methods is necessary to demonstrate that cell function or build shape remains to the development of regenerative tissue. GelMA had a critical role in this process and was conducive to accelerating the development of clinically relevant applications.
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