肝纤维化不同部位超声造影定量参数差异性的研究

摘要

Objective:To explore quantitative parameter difference by contrast-enhanced ultrasound(CEUS) in different position of the patients with hepatic fibrosis.Methods:The sixteen cases of hepatic fibrosis patients were confirmed by pathology,all patients were intravenous bolus injected with SonoVue 2.4 ml,and real-time dynamic imaging data of 3 min were collected and were analyzed off-line with the quantitative software.To record shallow liver parenchyma arrival time(SLP-AT) and shallow liver parenchyma arrival intensity(SLP-AI),middle liver parenchyma arrival time(MLP-AT) and middle liver parenchyma arrival intensity(MLP-AI),deep liver parenchyma arrival time(DLP-AT) and deep liver parenchyma arrival intensity(DLP-AI),their time to peak(TTP),peak to intensity(PI) and curve ascending slope(CAS).Results:Shallow liver parenchyma,middle liver parenchyma and deep liver parenchyma various parameters:MLP-AT is significantly shorter than the DLP-AT (P＜0.05),SLPAI is significantly lower than the MLP-AI and DLP-AI (P＜0.05),SLP-PI and MLP-PI is significantly higher than the DLP-PI (P＜0.05),SLP-CAS and MLP-CAS is significantly higher than the DLP-CAS(P＜0.05),TTP multiple comparison had no statistical significance(P＞0.05).Conclusion:Quantitative parameters of CEUS may reflect blood flow of perfusion characteristics in different position of the patients with hepatic fibrosis.%目的:探讨肝纤维化患者肝脏不同部位超声造影定量参数有无差异性.方法:研究对象为经病理证实的肝纤维化患者16例,均经肘静脉团注对比剂SonoVue 2.4 ml,采集实时动态造影数据3 min,使用超声造影定量分析软件进行脱机分析.分别记录浅层、中层、深层肝实质造影始增时间及强度,达峰时间、达峰强度和曲线上升斜率.结果:浅层、中层和深层肝实质各项参数中:中层肝实质造影始增时间较深层明显缩短(P＜0.05),浅层肝实质造影始增强度明显低于中、深层(P＜0.05),浅层肝实质达峰强度显著高于深层(P＜0.05),浅、中层肝实质曲线上升斜率显著高于深层(P＜0.05),达峰时间组间两两比较差异无统计学意义(P＞0.05).结论:超声造影定量参数可反映肝纤维化患者肝脏不同部位的血流灌注特征.