The developed regions are faced with the problems of regional comprehensive development, and the research on regional comprehensive development has become a trend in the world. To optimize regional industrial structure and to select and determine scientifically the spatial development strategy of regional industries are the central themes to be solved for the research on regional comprehensive development in the developed regions. This paper proposed the basis for optimizing regional industrial structure, and the main factors of selecting and determining the regional leading industries. Based on this, the paper puts forward the leading industries and the spatial development strategy in Shanghai-Nanjing-Hangzhou area in the future ten or more years. Combined with the situation of Shanghai-Nanjing-Hangzhou area, the paper also discusses some problems of locating superior developing axis to benefit the rational distribution of regional productive forces.
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