缺血性脑卒中患者血浆氧化低密度脂蛋白与预后的相关性研究

摘要

目的研究缺血性脑卒中患者血浆氧化低密度脂蛋白(ox-LDL)与其临床预后的相关性.方法 采用酶联免疫吸附 (ELISA)法测定60例健康体检者(对照组)和160例缺血性脑卒中患者(病例组)的血浆ox-LDL水平,对缺血性脑卒中患者进行神经功能缺损程度评分,并进行相关分析.结果 脑卒中患者急性期和恢复期的血浆ox-LDL水平分别为(747.1±76.5) μg/L和(502.7±86.2) μg/L,均高于对照组的血浆ox-LDL水平[(235.2±46.8) μg/L],差异有统计学意义( P ＜0.01);患者恢复期的ox-LDL水平与急性期的ox-LDL水平比较,差异亦有统计学意义( P ＜0.01).脑卒中患者急性期及恢复期的血浆ox-LDL水平与神经缺损程度评分呈正相关(r值分别为0.654和0.738,P ＜0.01).结论 血浆ox-LDL水平与缺血性脑卒中患者病情及预后有密切关系,有效地阻止脂质过氧化、减少ox-LDL的形成是缺血性脑卒中临床治疗的重要环节.%Objective To investigate the relationship between plasma levels of oxidized low density lipoproptein ( ox LDL) and prognosis in patients with stroke.Methods Plasma levels of ox - LDL were determined by ELISA method in 60healthy controls and 160 stroke patients.Degrees of neurologic impairment were evaluated.Correlations between ox - LDL levels and neurologic impairment degrees were analysed.Results The plasma ox - LDL levels of acute and recovery phases in the stroke group were ( 747.1 ±76.5 ) μg/L and ( 502.7 ±86.2 ) μ g/L respectively ( P ＜ 0.01 ) and were significantly higher than those in the control group [( 235.2 ±46.8 )μg/L]( P ＜ 0.01 ).Correlation analysis showed the scores of neurologic impairment in both acute and recovery phases of stroke were positively correlated to ox - LDL levels ( r = 0.654, r = 0.738, P ＜0.01 ).Conclusion Levels of plasma ox - LDL may have a close relationship with the prognosis of stroke patients.Effective prevention of lipid peroxidation to reduce the formation of ox - LDL in stroke patients plays an important role in the treatment of stroke.