Objective To explore the clinical significances of Th1/Th2 and Tc1/Tc2 cells imbalance in patients with hepatitis B. Methods The different T cell subtypes ( IFN - γ and IL - 4 ) were assessed by flow cytometry. The Th1/Th2 and Tc1/Tc2 levels between acute and chronic hepatitis B and among slight, moderate, and severe chronic hepatitis B were compared. Results The Th2 and Tc2 levels were significantly higher in chronic hepatitis B than in acute chronic hepatitis B ( t =- 3. 54, P =0. 001 ; t = - 2. 27 , P =0. 026 ) . Compared with the slight group, Thl and Tc1 levels were significantly higher in the moderate and severe groups ( P ＜ 0. 01 ) . Compared with the moderate group , Th1 and Tc1 levels were significantly higher in the severe group ( P ＜ 0. 05 ) . Conclusion Th2 and Tc2 levels are associated with chronic inflammation in hepatitis B cases. Thl and Tc1 levels increase with the increased inflammatory activity in hepatitis B cases.%目的 探讨外周血Th1/Th2、Tc1/Tc2细胞失衡在乙型肝炎中的临床意义.方法 采用流式细胞术分析乙型肝炎患者外周血不同T淋巴细胞亚群中细胞因子γ-干扰素(IFN-γ)和白介素4(IL-4)表达率的变化,分别比较急慢性乙型肝炎以及慢性轻、中、重度肝炎Th1/Th2、Tc1/Tc2的变化.结果 慢性乙型肝炎Th2、Tc2细胞均高于急性乙型肝炎(t=-3.54,P=0.001;t=-2.27,P=0.026);相对于轻度组,中度以及重度组Th1、Tc1均有升高(P＜0.01);相对于中度组,重度组Th1、Tc1亦有增高(P＜0.05).结论 乙型肝炎外周血Th2、Tc2细胞与炎症慢性化有关;随着慢性乙型肝炎活动程度的加剧,Th1、Tc1细胞逐渐增多.
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