不同程度糖尿病足溃疡风险患者血浆胰岛素样生长因子1水平的变化及意义

摘要

Objective To explore the changes of insulin like growth factor 1 ( IGF - 1 ) in patients with different risks of diahetic foot ulcers. Methods The clinical biochemical indices and plasma IGF - 1 levels were determined in 126 diabetic patients divided into groups high - risk ( n =25 ), moderate - risk ( n =32 ), mild - risk ( n = 30 ), non - risk ( n =39 ), and in control group ( n = 20 ). Results The levels of plasma IGF - 1 were significantly lower in diabetic groups than in control group ( P ＜0. 05 ), and in high - risk group than in groups mild - risk and non - risk ( P ＜ 0. 05 ). Plasma IGF - 1 was negatively correlated with courses of diseases, HhA1c , 24 h urine protein excretion ( P ＜ 0. 05 ). Conclusion The decrease of plasma IGF - 1 may increase the risk of diabetic foot ulcer.%目的 探讨不同程度糖尿病足溃疡风险患者血浆胰岛素样生长因子1(IGF-1)水平的变化及其意义.方法 选取2型糖尿病患者126例,其中糖尿病足溃疡高度风险组25例,中度风险组32例,轻度风险组30例,无风险组39例,另设正常对照组20例,测定临床生化指标及血浆IGF-1水平.结果 糖尿病各组血浆IGF-1水平均低于正常对照组,差异均有统计学意义(P＜0.05),糖尿病足溃疡高度风险组患者血浆IGF-1水平明显低于轻度风险组及无风险组,差异均有统计学意义(P＜0.05).血浆IGF-1水平与病程、糖化血红蛋白(HbA1c)、24 h尿蛋白定量呈负相关(P＜0.05).结论 糖尿病患者血浆IGF-1水平下降可能与糖尿病足溃疡风险增加有重要关联.