Objective To evaluate the clinical effect of Jiaogulanzongdai Tablet combined with Shanzhajing Tablet on HAART - associated dyslipidemia. Methods 60 AIDS patients with HAART - associated dyslipidemia were randomly divided into experimental group ( 40 cases ) and control group ( 20 cases ) . The patients in the experimental group were given Jiaogulanzongdai Tablets and Shanzhajing Tablets, 1 tablet a time PO and 3 times daily for 6 weeks. The patients in the control group were given Atorvastation Calcium Tablets, 1 tablet a time PO and 1 time daily for 6 weeks. Serum total cholesterol ( TC ), triglyceride ( TG ), low - density lipoprotein cholesterol ( LDL - C ) and high - density lipoprotein cholesterol ( HDL - C ) were detected and compared before and after treatment between the two groups. Results The blood lipid indicators before treatment between the two groups showed no statistically significant differences ( P > 0. 05 ) . After treatment, the levels of TC, TG and HDL - C in the experimental group were significantly higher than those of the control group ( P < 0. 05 ) . The LDL - C between the two groups showed no statistically significant difference ( P = 0. 06 ) . Conclusion Jiaogulanzongdai Tablet combined with Shanzhajing Tablet can improve HAART - associated dyslipidemia. This regimen is less efficient in lowering TC and TG, and similar efficient in lowering LDL - C and more efficient in raising HDL - C compared with Atorvastation Calcium Tablet.%目的 观察绞股蓝总甙片联合山楂精降脂片治疗高效抗逆转录病毒治疗(HAART)后血脂异常的疗效.方法 将60例HAART后血脂异常的艾滋病患者随机分为试验组(40例)和对照组(20例).试验组给予绞股蓝总甙片和山楂精降脂片,两药均为1片/次,3次/d;对照组给予阿托伐他汀钙片,1片/次,1次/d.两组均连续服药6周.比较两组服药前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平.结果 治疗前两组间TC、TG、LDL-C、HDL-C水平间差异均无统计学意义(P＞0.05).治疗后,试验组TC、TG和HDL-C高于对照组,差异均有统计学意义(P＜0.05);两组LDL-C水平间差异无统计学意义(P=0.06).结论 绞股蓝总甙片联合山楂精降脂片可改善HAART后血脂异常,降低TC和TG的效果不及阿托伐他汀钙片,降低LDL-C的效果与阿托伐他汀钙片接近,提高HDL-C的效果优于阿托伐他汀钙片.
展开▼
