Objective To compare the short - term clinical efficacy of Tangmaikang and intensive life style intervention on patients with impaired glucose regulation ( IGR ) . Methods 60 patients with IGR selected from four communities and our hospital were randomly divided into control group ( 30 cases ) and the TCM group ( 30 cases ) . Patients of the two groups were firstly given health education. The subjects in the control group were given individually designed diet and exercise program, while the subjects in the TCM group were given Tangmaikang twice daily with each time 5 g for three months. The life styles of the two groups' patients were not changed. FPG, 2 hPG, FINS, TC, TG, waist circumference and BMI of the two groups before treatment and three months after treatment were compared between the two groups. HOMA - IR was assessed by homeostasis model and group t test or paired t test was used for measurement data and χ2 test was used for enumeration data. Results A total of 5 cases ( 8. 3% ) out of the 60 cases dropped out of the study, 3 cases from TCM group and two cases from control group. At the end of the observation period, no people converted to diabetes. 15 cases ( 55. 6% ) from TCM group and 20 cases ( 71. 4% ) from control group converted to normal glucose tolerance ( NGT ), and the difference between the two groups was not statistically significant ( P > 0. 05 ) .FPG, 2hPG, FINS, HOMA-IR, TC, TG, waist circumference and BMI between the two groups before treatment showed no statistically significant differences ( P > 0. 05 ) . After treatment, the above indicators also showed no statistically significant differences ( P > 0. 05 ) . After treatment, FPG, 2 hPG, TG, waist circumference and BMI were significantly decreased compared with before treatment ( P < 0. 05 ) . In TCM group, TC level was significantly decreased after treatment compared with before treatment ( P < 0. 05 ) . Conclusion Tangmaikang can delay or prevent IGR becoming diabetes and can effectively reduce the levels of blood glucose, blood lipid and improve waist circumference and BMI, equaling the efficacy of intensive life style intervention.%目的 探讨中成药糖脉康与强化生活方式对糖调节受损(IGR)患者短期干预的效果.方法 按美国糖尿病协会(ADA)2003年IGR诊断标准,从2005年上海市卢湾区打浦、淮海、五里、瑞金4个街道的糖尿病一级预防重点人群中筛选出部分IGR患者及我院住院、体检者中的IGR患者共60例.将其随机分为中药组(30例)和对照组(30例).两组患者均先进行一次健康生活方式宣教.然后对照组给予强化饮食、运动治疗.中药组给予中成药糖脉康治疗,1包/次(5 g/次),2次/d,治疗3个月;对患者的生活方式不作要求.观察并比较治疗前及治疗3个月后两组患者的空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、腰围,根据身高、体质量计算体质指数(BMI).采用稳态模型评价胰岛素抵抗指数(HOMA-IR).计量资料采用成组t检验或配对t检验;计数资料采用χ2检验.结果 60例受试者共有5例(8.3%)退出本研究,其中中药组3例,对照组2例.观察期结束时两组均无一例转为糖尿病;中药组有15例(55.6%)、对照组有20例(71.4%)转为正常糖耐量,两组比较差异无统计学意义(P＞0.05).治疗前两组患者FPG、2 hPG、FINS、HOMA-IR、TC、TG、腰围、BMI比较,差异均无统计学意义(P＞0.05);治疗后两组患者上述指标比较,差异亦无统计学意义(P＞0.05).但治疗后两组FPG、2 hPG、TG、腰围、BMI均较治疗前显著下降,中药组TC水平亦较治疗前显著下降,差异均有统计学意义(P＜0.05).结论 糖脉康具有延缓或预防IGR向糖尿病发展的作用,能有效降低血糖、血脂,改善腰围、BMI,具有与强化生活方式干预相当的疗效.
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