原发灶不明转移癌的诊断与治疗进展

摘要

原发灶不明转移癌(CUP)占所有恶性上皮肿瘤的3%~5%.CUP的诊断方法包括免疫组化检查、影像学技术及基因芯片.CUP分为预后良好组和预后不良组,前者可得益于局部手术或放疗、以铂类或紫杉醇类为基础的全身性化疗;后者则表现出对治疗的抗拒性,以铂类为基础的经验性化疗并不能提高其生活质量或延长生存期.%Cancers of unknown primary ( CUP ) account for 3% ~ 5% of all malignant epithelial tumors. The CUP diagnostic approaches include immunohistochemical examination, imaging technology and gene chips. CUP can be divided into groups good prognosis and poor prognosis. The former can benefit from local surgery or radiotherapy, platinum - or paclitaxel -based systemic chemotherapy; The latter show treatment resistance, and platinum - based empiric chemotherapy can not improve their quality of life or prolong their survivals.