功能性胃肠病与围绝经期综合征的关系研究

摘要

目的：探讨功能性胃肠病与围绝经期综合征（ MS）的关系。方法选取2008年1月—2012年12月到宜昌市中心人民医院消化内科就诊的女性功能性胃肠病患者120例。根据改良版更年期症状评分量表（ Kupperman）得分，将患者分为非MS组（n＝41）和MS组（n＝79）。采用问卷调查的方法，收集患者一般资料和消化症状评分。比较两组患者的消化症状，探讨消化症状评分与Kupperman得分的相关性。结果120例患者中，合并MS的患者数为79例（占65.8％）。非MS组和MS组平均年龄、平均病程及婚姻状况比较，差异无统计学意义（ P﹥0.05）。非MS组和MS组平均消化症状评分比较，差异有统计学意义（ P﹤0.05）。两组腹痛、腹胀、便秘、吞咽梗阻感症状发生率比较，差异有统计学意义（P ﹤0.05）；而胃灼热、早饱、恶心、呕吐、腹泻症状发生率比较，差异无统计学意义（P ﹥0.05）。两组消化症状数量比较，差异无统计学意义（ P﹥0.05）。Pearson相关分析显示，消化症状评分与Kupperman得分呈正相关关系（r＝0.34，P﹤0.05）。结论功能性胃肠病与MS存在正相关关系，临床医生在治疗中老年女性功能性胃肠病患者时，应考虑到MS的影响。%Objective To explore relationship between functional gastrointestinal disease( FGD)and menopausal syndrome(MS). Methods From January 2008 to December 2012,120 female FEG patients who received treatment in the department of gastroenterology of Yichang Central People's Hospital were enrolled. According to the scores of revised menopausal symptoms rating scale(Kupperman),the patients were divided into non-MS group(n=41)and MS group(n=79). Using questionnaire survey,we collected the general data and scores of digestive symptoms. Comparison was made between the two groups in the scores of digestive symptoms and Kupperman score. Results Among the 120 patients,the number of patients with MS was 79(65. 8%). The two groups were not significantly different in average age,average length of disease and marital status(P﹥0. 05 for all). The two groups were significantly different in the average score of digestive symptoms(P﹤0. 05). The two groups were significantly different in the numbers of patients with swallowing obstruction, abdominal distension, abdominal pain and constipation ( P ﹤0. 05 for all );while the two groups were not significantly different in the number of patients with heartburn,early satiety,nausea,vomit and diarrhea(P﹥0. 05 for all). The two groups were not significantly different in the number of digestive symptoms ( P ﹥0. 05 ) . Pearson correlation analysis showed that the score of digestive symptoms and Kupperman score were positively correlated with each other(r =0. 34,P ﹤0. 05). Conclusion FGD has positive correlation with MS. Doctors should take the influence of MS into consideration in the treatment of middle aged and elderly female patients with FGD.