新疆地区不同临床分型帕金森病患者影响因素分析

摘要

Objective To investigate the influencing factors for Parkinsion's disease( PD)patients with different clinical type in Xinjiang,to provide a theoretical basis for early prevention and treatment of disease. Methods By using the method of retrospective study,259 patients who were diagnosed with PD in the First Affiliated Hospital of Xinjiang Medical University from January 2004 to December 2013, were selected as study subjects. The age, gender, nationality, smoking history,drinking history,history of tea drinking,history of pesticide contact,positive family history,history of hypertension, history of diabetes,the degree of education,occupation and body mass index( BMI)of patients were investigated. Results 142 cases were classified as tremor type,90 cases were classified as akinetic - rigid type,27 cases were classified as mixed type. There were significant differences in age among tremor type PD patient group,akinetic-rigid type PD patient group and mixed type PD patient group(P﹤0. 05). The PD patients' clinical type with different nationality,smoking history,history of tea drinking,history of pesticide contact and occupation showed statistical differences( P﹤0. 05 ) . The patients' clinical type with different gender,drinking history,positive family history,history of hypertension,history of diabetes,education degree and BMI showed no statistical difference( P ﹥0. 05 ) . According to the results of multivariate logistic regression analysis, nationality,and history of tea drinking had a regressive relationship with tremor type,respectively;age and smoking history had a regressive relationship with akinetic - rigid type, respectively;nationality had a regressive relationship with mixed type, respectively(P﹤0. 05). Conclusion The most common PD types are tremor type and akinetic-rigid type,PD patients with different clinical type has different age,few tremor type PD patients are Han or tea drinkers,the most common type among old PD patients or smoker PD patients is akinetic-rigid type,the most common type among Han PD patients is mixed type.%目的：探讨新疆地区不同临床分型帕金森病（ PD）患者的影响因素，为疾病的早期预防和治疗提供理论依据。方法采用回顾性研究的方法，选取2004年1月—2013年12月新疆医科大学第一附属医院确诊的PD患者259例，调查患者的年龄、性别、民族、吸烟史、饮酒史、饮茶史、农药接触史、阳性家族史、高血压病史、糖尿病病史、文化程度、职业、体质指数（ BMI）等。结果震颤型142例、强直-少动型90例、混合型27例。震颤型、强直-少动型、混合型PD患者年龄比较，差异有统计学意义（ P﹤0.05）。不同民族、吸烟史、饮茶史、农药接触史、职业PD患者临床分型不同，差异有统计学意义（ P﹤0.05）。不同性别、饮酒、阳性家族史、高血压病史、糖尿病病史、文化程度、BMI PD患者临床分型比较，差异无统计学意义（ P﹥0.05）。多因素Logistic回归分析结果显示，民族、饮茶史与震颤型有回归关系，年龄、吸烟史与强直-少动型有回归关系，民族与混合型有回归关系（ P﹤0.05）。结论 PD患者以震颤型和强直-少动型为主，不同临床分型PD患者年龄分布不同，汉族、饮茶者较少以震颤型起病，高龄、吸烟者主要以强直-少动型起病，汉族主要以混合型起病。