头孢硫脒应用于小儿急性细菌性呼吸道感染治疗的临床研究

摘要

Objective:To study the clinical curative effect of acute bacterial respiratory cefathiamidine on infection in children and compared with ceftazidime.Method:Collecting pediatric hospital treatment of 118 cases of children with bacterial respiratory system infection in our hospital,they were randomly divided into two groups.The observation group was given the cefathiamidine(Baiyun Mountain pharmaceutical factory);The control group were treated with ceftazidime (New Shanghai pioneer Pharmaceutical Co. Ltd),observing clinical cure rate,bacterial clearance rate and the incidence of adverse reactions of the two groups.Result:Observation group had a cure rate of 54.8%,markedly effective rate of 35.5%,total effective rate of 93.5%and bacterial clearance rate of 85.2%,the adverse reaction incidence was 6.5%,there were no significant difference compared with the control group(P>0.05).Conclusion:Low-dose sulfur cephalosporin amidine bacterial acute respiratory infection in children with obvious therapeutic effect can be comparable to the three generations of cephalosporins. The totally antimicrobial treatment effect was high and the cost was low,and the adverse reactions can be tolerated.It is worthy of clinical application.%目的：探讨头孢硫脒治疗儿童急性细菌性呼吸道感染的临床疗效，并与头孢他啶进行比较。方法：选择近期在笔者所在医院儿科治疗的118例细菌性呼吸系统感染患儿，随机分为两组，观察组予头孢硫脒(白云山制药总厂)，对照组予头孢他啶(上海新先锋药业有限公司)，观察两组临床治愈率、细菌清除率及不良反应发生率。结果：观察组痊愈率54.8%，显效率35.5%，总有效率93.5%，细菌清除率为85.2%，不良反应的总发生率为6.5%，与对照组比较差异均无统计学意义(P>0.05)。结论：小剂量头孢硫脒治疗儿童细菌性急性呼吸道感染疗效显著，可媲美三代头孢他啶抗菌素的治疗效果且费用较低，不良反应少，值得临床应用。