纤溶酶对急性脑梗死患者脑血管储备功能的影响

摘要

目的：研究纤溶酶对急性脑梗死患者脑血管储备功能的影响。方法：将70例急性脑梗死患者按照随机对照双盲的实验原则，分为治疗组和对照组，每组35例，两组均给予常规治疗，对照组加用安慰剂，治疗组加用纤溶酶。采用TCD评估脑血管储备功能，NIHSS评分评估神经功能。结果：治疗组治疗后与治疗前、对照组比较，大脑中动脉MFV、CVR、BHI均有增加，在PI、NIHSS方面比较，均有减少，差异有统计学意义(P<0.05)；对照组治疗前较治疗后大脑中动脉MFV、CVR、BHI均增加，PI、NIHSS下降，差异有统计学意义(P<0.05)。治疗前，对照组与治疗组在NIHSS评分方面，大脑中动脉MFV、PI、CVR、BHI的比较，差异均无统计学意义(P>0.05)。结论：纤溶酶可改善急性脑梗死患者脑血管储备功能并改善神经功能。%Objective:The fibrinolytic enzyme effect of cerebrovascular reserve function in patients with acute cerebral infarction.Method:To 70 cases of acute cerebral infarction patients,in accordance with the principle of randomized double-blind experiments were divided into experimental group and control group,35 cases in each group,both groups were given conventional therapy,the control group with placebo,the treatment group with fibrinolytic enzyme. Using TCD to assess cerebrovascular reserve function,NIHSS score evaluation of nerve function.Result:Treatment group after treatment compared with before treatment, the control group,middle cerebral artery MFV,CVR,BHI had increased,in PI,NIHSS,are reduced,the difference was statistically significant (P<0.05);In the control group before than after treatment in the brain artery MFV,CVR,BHI all increase,PI,NIHSS decreased,the difference was statistically significant (P<0.05). Before the treatment,control group and treatment group in the NIHSS score,middle cerebral artery MFV,PI,CVR,the comparison of BHI,there were no statistically significant difference (P>0.05).Conclusion:Fibrinolytic enzymes can improve cerebrovascular reserve function in patients with acute cerebral infarction and improve nerve function.