25-羟维生素D水平与妊娠期细菌性阴道病发生率的关系

摘要

Objective:To discuss the relationship between the level of pregnant women’s serum 25-(OH)D and the incidence rate of pregnancy bacterial vaginal disease (BV).Methods:All the 400 cases of the pregnant women for the gestation period in 10-12 and 24-28 weeks from 2011 to 2012 in our hospital were selected.All the pregnant women were examined the test of the serum 25-(OH)D and the BV inspection.To analyse the correlation between the test of the serum 25-(OH)D and the BV inspection.Results:In local region,the incidence rate was 52.3%when 25-(OH)D was deficiency(≤50.0 nmol/L) for 10-12 weeks early pregnant women,30.5%when it was shortage(50.0 nmol/L<25-(OH)D≤75.0 nmol/L) and 17.3%was normal(>75.0 nmol/L),which relevant incidence rate of BV was 32.1%,23.8%and 5.9%.On the other hand,the incidence rate was 61.8%when 25-(OH)D was deficiency for 24-28 weeks late pregnant women,32.8%when it was shortage and 5.5%was normal,which relevant incidence rate of BV was 40.9%,32.1%and 9.1%.The 25-(OH)D in 24-28 weeks of pregnancy appear obvious anomaly more than 10-12 weeks pregnant women,Vitamin D down significantly,BV infection rate increased significantly.BV incidence in 25-(OH)D deficiency and lack were patency higher than the 25-(OH)D normal(P<0.05).Conclusion:The incidence rate of pregnancy bacterial vaginal disease is closely related to the deficiency of Vitamin D in pregnant women.%　　目的：探讨妊娠妇女血清25-羟维生素D水平与妊娠期细菌性阴道病(BV)发生率的关系。方法：对2011-2012年来笔者所在医院进行产检的妊娠期10~12周及24~28周的孕妇各400例进行血清25-(OH)D检测，并取阴道分泌物进行BV检查，对其相关性进行分析。结果：笔者所在地区孕10~12周孕早期妇女25-(OH)D缺乏(≤50.0 nmol/L)的发生率为52.3%，25-(OH)D不足(50.0 nmol/L<25(OH)D≤75.0 nmol/L)的发生率为30.5%，25-(OH)D正常者(>75.0 nmol/L)占17.3%，其相对应的BV的发生率分别为32.1%、23.8%、5.8%。妊娠24~28周孕晚期妇女25-(OH)D缺乏的发生率为61.8%，25-(OH)D不足的发生率为32.8%，25-(OH)D正常者占5.5%，其相对应的BV的发生率分别为40.9%、32.1%、9.1%。对两组进行比较，妊娠24~28周孕妇25-(OH)D异常高于孕10~12周，维生素D下降明显，相对应出现BV感染率显著高。25-(OH)D不足和缺乏的孕妇中BV发生率高于25-(OH)D正常的孕妇(P<0.05)。结论：妊娠期细菌性阴道病的发生率与25-羟维生素D缺乏密切相关。