血清胱抑素C与多种血清学指标在慢性心力衰竭患者中的表达及相关性

摘要

Objective:To discuss the changes of serum cystatin C and some of serum marker in patients with chronic heart failure,and provide the basis of sensitive index for patients with heart failure prediction.Method:57 patients with CHF were examined by UCG after admission,and 57 patients(no history of heart failure) were chosen as control from February to December 2013 in our hospital.The level of serum Cys C,creatinine(SCr),blood urea nitrogen(BUN), left ventricular ejection fraction(LVEF),plasma B type natriuretic peptide(BNP) were measured in them.Result:Compared with the control group,there were statistically significant differences between Cys C,BUN,SCr(P<0.05) among NYHA’S heart function class,and with the grade of heart function increased,the serum Cys C,BNP also increased significantly(P<0.01);at the same time,the concentration of Cys C had a parallel relationship with BNP,heart function class and the blood pressure in patients(P<0.01).Conclusion:The combined detection of serum cystatin C and BNP can identify high-risk patients with chronic heart failure,it has a predictive value for cardiac and renal syndrome.%目的：利用血清胱抑素C(Cystatin，Cys C)及多种血清学指标在慢性心力衰竭(chronic heart failure，CHF)患者血清中的表达，为心力衰竭患者病情预测寻找敏感指标提供依据。方法：选择2013年2-12月因心力衰竭入住笔者所在医院心内科的患者57例，以同期健康体检者57例为对照组，分别测定Cys C、血清肌酐(SCr)、尿素氮(BUN)、左心室射血分数(LVEF)等水平，并进行统计分析。结果：不同心功能分级Cys C、BUN、SCr与对照组相比差异有统计学意义(P<0.05)，且随着心功能级别增加血清Cys C、BNP亦显著增加，差异有统计学意义(P<0.01)；同时血清Cys C的表达与心功能分级、BNP及患者血压具有相关性。结论：联合检测血清胱抑素C、血浆BNP能够识别慢性心力衰竭高危患者，对预防重症的发生有预测价值。