3600例健康体检者肺炎衣原体和肺炎支原体的血清学分析

摘要

目的：了解肺炎衣原体和肺炎支原体在人群中的流行分布等情况，为呼吸道感染提供预防帮助。方法：选2013年1-12月到笔者所在医院的健康体检者，其中儿童组(年龄4~14岁)1200例为A组；青中年组(年龄18~40岁)1200例，为B组；老人组(60~80岁)1200例为C组，三组研究对象均抽静脉血，用酶联免疫吸附法(ELISA)检测血清肺炎支原体和衣原体特异性IgG、IgM抗体。分析MP和CP感染与患者年龄、季节及感染所占的百分比。结果：3600例体检者中CP、MP总感染率分别为54.64％、45.33％，其中急性感染率分别为3.66％、2.25％，慢性感染率分别为1.40％、0.75％，既往感染率分别为49.58％、42.33％。C组感染率CP最高，A组感染率MP最高，全年均有感染，但冬季感染率最高。A、B、C组CP IgM和IgG抗体阳性率分别为2.75％和47.00％、3.75%和50.00%、4.5%和51.75%，A、B、C组CP IgM+IgG同时阳性率别为1.00%、1.50%和1.75%；A、B、C组MP IgM和IgG抗体阳性率分别为3.25％和45.00％、2.00%和42.00%、1.50%和40.00%，A、B、C组MP IgM+IgG同时阳性分别为：1.00%、0.75%、0.50%。A、B、C三组CP和MP IgM和IgG抗体阳性率比较差异均有统计学意义(P<0.05)。结论：肺炎衣原体肺炎和肺炎支原体在人群中均存在无症状感染，且感染率不低，这些可能与肺炎衣原体和肺炎支原体感染发病率高有密切关系，特别是儿童和老人，实行确实有效的预防措施已成为迫切的需要。%Objective:To study the the population distribution situation of pneumoniae chlamydia and pneumoniae mycoplasma prevalence for respiratory infection prevention help.Method:3600 cases in our hospital healthy from January 3013 to December 2013 were selected,which were divided into three groups, Children group(ages 4-14 years) 1200 cases of A group,young adult group(ages 18-40 years old) 1200 cases for the B group,elderly group(60-80 years old) 1200 cases of group C,three groups of subjects were pumping blood,serum mycoplasma pneumoniae and chlamydia specific IgG and IgM antibodies by enzyme-linked immunosorbent assay(ELISA).MP and CP infection and age,season and the percentage of infected patients share were analysed.Result:3600 cases of physical examination in CP,MP overall infection rates were 54.64%,45.33%,which was 3.66% of acute infection,2.25%,chronic infection were 1.40%,0.75%, previous infection rates were 49.58%,42.33%.CP in C group was the highest infection rate,MP in A group was the highest infection rate,infection throughout the year,but in winter was the highest infection rate.A,B,C group CP IgM and IgG antibody positive rates were 2.75% and 47.00%,3.75% and 50.00%,4.5.%and 51.75%,A,B,C group CP IgM+IgG positive rate were 1.00%,1.50% and 1.75%,A, B, C group MP IgM and IgG antibody positive rates were 3.25%and 45.00%,2.00% and 42.00%,1.50% and 40.00%,A,B,C group MP IgM+IgG simultaneously positive were 1.00%,0.75%,0.50%.A,B,C three groups CP and MP IgM and IgG antibody positive rate compared,the differences were statistically significant(P<005).Conclusion:Chlamydia pneumoniae and mycoplasma pneumoniae are present in the crowd asymptomatic infection,and the infection rate is not low,which may be associated with chlamydia pneumoniae and mycoplasma pneumoniae infection incidence closely,especially children and the elderly,to implement truly effective preventive measures has become an urgent need.