肿瘤标志物检测在肺癌诊断中的临床意义

摘要

Objective:To investigate the significance of the quantity of the serum CEA,CYFRA21-1,CA125 and NSE of patients with lung cancer in the clinical types and pathological types of lung cancer.Method:The serum samples of 104 patients with lung cancer and 50 patients with benign lung diseases were measured.Result:The quantity of the serum CEA,CYFRA21-1,CA125 and NSE of patients with lung cancer were higher than that of patients with benign lung diseases.The positive rate of CEA in stageⅣadenocarcinoma was highest.The positive rate of CYFR21-1 in stageⅣadenocarcinoma and stageⅣsquamous cell carcinoma was higher than other stages.The positive rate of CA125 in stageⅠ-Ⅳadenocarcinoma was higher than other lung cancers.The positive rate of CEA and CA125 and the clinical stage of adenocarcinoma and squamous cell carcinoma were significantly correlated.Conclusion:CEA,CYFRA21-1,CA125 and NSE can be used as screening indicators of lung cancer.The level of tumor markers was significantly correlated with the clinical stage and pathological type of lung cancer.%目的：评价癌胚抗原(CEA)、血清细胞角蛋白19片段抗原(CYFRA21-1)、糖类抗原125(CA125)及神经元特异烯醇化酶(NSE)水平在肺癌临床分型、判断病理类型中的意义。方法：对肺癌组104例、肺良性病变组50例患者的CEA、CYFRA21-1、NSE、CA125进行综合比较。结果：肺癌组患者CEA、CYFRA21-1、CA125、NSE水平均高于肺良性病变组，差异有统计学意义(P<0.05)；CEA在腺癌IV期中阳性率最高， CYFRA21-1在腺癌Ⅳ期、鳞癌Ⅳ期中阳性率最高，CA125在腺癌Ⅰ~Ⅳ期阳性率均最高，且腺、磷癌中CEA、CYFRA21-1临床分期越晚，阳性率越高，存在明显差异。结论：CEA、CYFRA21-1、CA125、NSE均可作为肺癌筛查的指标。另外，不同肿瘤标志物的阳性率对临床分型、病理类型有一定的参考意义。