重组组织型纤溶酶原激活剂早期静脉溶栓治疗急性脑梗死的疗效观察

摘要

目的：观察重组组织型纤溶酶原激活剂早期静脉溶栓治疗急性脑梗死的疗效。方法：选取2012年12月-2013年12月笔者所在医院收治的36例急性脑梗死患者，将其随机分成观察组18例与对照组18例，观察组给予重组组织型纤溶酶原激活剂(rt-PA)0.8 mg/kg进行静脉溶栓，给予对照组患者常规的活血化瘀治疗，比较两组治疗前、治疗后1、7、14 d的NIHSS评分。结果：治疗后1、7、14 d观察组的NIHSS评分优于对照组，90 d后治疗总有效率明显高于对照组，差异有统计学意义(P<0.05)。结论：rt-PA静脉溶栓对急性脑梗死的治疗，可以促进神经功能的早期恢复，改善患者90 d的预后，且越早治疗其溶栓的效果越好。%Objective:To observe the curative effect of early intravenous thrombolysis with rt-PA in the treatment of acute cerebral infarction.Method:36 patients with acute cerebral infarction who were being treated at our hospital from December 2012 to December 2013 were selected,they were randomly divided into the observation group (18 cases) and the control group(18 cases),the observation group were treated through intravenous thrombolytic with rt-PA(0.8 mg/kg), the control group were used activating blood and resolving stasis,the NIHSS score of the two groups before and after treatment of 1,7,14 d was compared. Result:After the treatment of the first,the 7th days,the 14th days,the NIHSS score in the observation group were better than control group,the total efficiency after 90 d was significantly higher than the control group,the difference were statistically significant(P<0.05).Conclusion:Intravenous thrombolysis with r-TPA in the treatment of acute cerebral infarction can promote early recovery of neurological function,improve the prognosis after 90 d,and the earlier treatment begins the better the effect of thrombolysis.