足月小于胎龄儿Ghrelin及IGF-1水平与生长追赶的关系探讨

摘要

目的：探讨足月小于胎龄儿(SGA)Ghrelin、IGF-1水平和生长追赶(CUG)的相关性。方法：选取足月SGA(研究组)与适于胎龄儿(AGA，对照组)各50例，对比两组出生后第3天的Ghrelin、IGF-1水平，并比较有CUG的SGA(研究组1)、无CUG的SGA(研究组2)及对照组在出生1个月与1年的Ghrelin、IGF-1，分析三组出生1年后Ghrelin、IGF-1与身长、体重、头围、BMI的相关性。结果：与对照组比较，研究组出生第3天SGA的Ghrelin更高，IGF-1更低(P<0.05)；出生1个月与1年后研究组2的Ghrelin、IGF-1与对照组相比差异有统计学意义(P<0.05)；Ghrelin与体重、BMI呈负相关性，IGF-1与体重呈正相关性。结论：对出生1个月后体重偏低的SGA应及时行Ghrelin、IGF-1检测，并及早促进CUG水平，降低SGA生长发育异常率。%Objective:To discuss the relationship between Ghrelin,IGF-1 levels and CUG of small full-term gestational age(SGA).Method:50 cases of SGA(the research group) and 50 cases of AGA(the control group) were selected,all were compared Ghrelin,IGF-1 of the two groups on the third day of birth, and compared Ghrelin,IGF-1 leve of SGA who had CUG(the research group 1),SGA who had no CUG(the research group 2) and the control group after born 1 month and 1 year,and analysed the relationship of Ghrelin,IGF-1 and body length,body weight,head circumference,BMI of the three groups after born 1 year.Result:The Ghrelin level was higher and the IGF-1 level of the research group was lower than those in the control group on the third day of birth(P<0.05), after born 1 month and 1 year and there had obvious difference between the research group 2 and the control group on Ghrelin,IGF-1(P<0.05).Ghrelin and body weight,BMI had negative correlation,IGF-1 and body weight had positive correlation.Conclusion:SGA whose has low weight after born 1 months should test Ghrelin and IGF-1 and promote the level of catch-up growth in time,to reduce the rate of abnormal growth of SGA.