肝硬化患者血小板参数变化及临床意义

摘要

目的：探讨肝硬化患者血小板参数的变化及临床价值。方法：用血液分析仪检测128例肝硬化患者(肝硬化组，其中出血组32例，无出血组96例)的血小板参数指标，与110例健康对照组的血小板参数比较。结果：肝硬化组与健康对照组比较，血小板计数(PLT)和血小板压积(PCT)低于健康对照组，平均血小板体积(MPV)、血小板分布宽度(PDW)和大血小板比率(P-LCR)高于健康对照组，差异有统计学意义(P<0.05)。出血组PLT和PCT低于无出血组，而出血组MPV、PDW和P-LCR均高于无出血组，差异有统计学意义(P<0.05)。结论：肝硬化患者的血小板存在质量和数量方面的异常，血小板参检测可以反映肝硬化患者肝细胞损伤程度，为临床对病情判断、治疗及预后提供有价值的参考依据。%Objective:To investigate the changes and clinical value of platelet parameters in patients with cirrhosis.Method:To detect parameter index with blood analyzer for 128 cases of cirrhosis platelet,and compare with 110 cases of platelet parameters in healthy control group.Result:The platelet count(PLT) and platelet hematocrit(PCT) in cirrhosis group were lower than the healthy control group,the mean platelet volume (MPV),platelet distribution width (PDW) and large platelet ratio(P-LCR) in cirrhosis group were higher than the healthy control group,the differences were statistically significance(P<0.05).The platelet count(PLT) and platelet hematocrit(PCT) in bleeding group were lower than non-bleeding group,the mean platelet volume(MPV),platelet distribution width(PDW) and large platelet ratio(P-LCR) in bleeding group were higher than the non-bleeding group,the differences were statistically significance(P<0.05). Conclusion:The platelets of cirrhosis patients have abnormal aspects of quality and quantity,detection of platelet parameters may reflect the degree of liver cell injury for patients with cirrhosis,for clinical judgment of the disease,treatment and prognosis providing valuable reference.