肝硬化患者外周血血小板参数和单核细胞参数的变化及临床意义

摘要

Objective To explore the changes and clinical significance of parameters of peripheral blood platelets and parameters of monocytes for patients with liver cirrhosis. Methods 50 patients with liver cirrhosis in our hospital from October 2013 to October 2014 were selected as the observation group.The level of PLT,P-LCR,MPV,PDW,PCT,percent-age of monocytes and total number of monocytes in the observation group were tested via fully automatic hematology analyzer,and which was compared with that in the control group of 52 subjects with normal results of clinical physical examination. Results The level of PCT and PLT in the observation group was lower than that in the control group,with significant difference (P<0.05),and the abnormal degree of differences of PCT and PLT gradually became severe along with the increasing Child-Pugh level (P<0.05).PDW,MPV and P-LCR was higher than that in the control group with significant difference(P<0.05),and the abnormal degree of differences of all values above gradually became severe along with the increasing Child-Pugh level (P<0.05).Percentage of monocytes and total number of monocytes between two groups was no significantdifference (P>0.05). Conclusion Percentage of monocytes and total number of monocytes in peripheral blood for patients with liver cirrhosis do not show a significant change,but the parameter of blood platelets shows an abnormal change compared with healthy subjects.Changes of all parameters represent the degree of liver dam-ages,and mastering the changes of all parameters plays a significant role in clinical treatment.%目的：探讨肝硬化患者外周血血小板参数和单核细胞参数的变化及临床意义。方法选取本院2013年10月~2014年10月收治的50例肝硬化患者作为观察组，采用全自动血液分析仪检测其血小板计数(PLT)、大血小板比率(P-LCR)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)、血小板压积(PCT)、单核细胞百分比、单核细胞总数，并与52名临床体检正常的对照组进行比较。结果观察组的PCT、PLT水平显著低于对照组，差异有统计学意义(P<0.05)；PCT、PLT水平随着Child-Pugh分级的增加，差异异常程度逐渐加重(P<0.05)。观察组的PDW、MPV、P-LCR水平显著高于对照组，差异有统计学意义(P<0.05)，各数值随着Child-Pugh分级的增加，差异异常程度均逐渐加重(P<0.05)。两组的单核细胞百分比和单核细胞总数比较，差异无统计学意义(P跃0.05)。结论肝硬化患者外周血单核细胞百分比和单核细胞总数变化不明显，但血小板参数较正常健康者出现异常变化。各参数的变化反映着肝损伤程度，掌握各参数变化情况对临床治疗有着重要作用。