曲伏前列素对复合小梁切除术后眼压控制不良患者的疗效

摘要

目的：观察曲伏前列素用于复合小梁切除术术后眼压控制不良患者的疗效。方法：选择笔者所在医院行复合小梁切除术后眼压控制不良的13例青光眼患者，对其术后眼压控制资料进行回顾性分析，13例患者首先单纯采用曲伏前列素滴眼液控制眼压，如果患者仍然控制不良，则对其联合使用布林佐胺滴眼液控制眼压。比较和分析这13例患者用药前以及用药后第1、3、6、12个月的眼压、视野、视力、杯盘比以及OCT视神经纤维厚度的变化等情况。结果：9例患者在单纯采用曲伏前列素滴眼液治疗后眼压以及昼夜眼压差均控制在正常范围内，治疗有效率为69.2%。在视野缺损情况的比较中，13例患者的视野缺损均无加重；随访过程中13例患者的视力无下降，杯盘比无增大，视神经纤维无进一步变薄，用药期间无一例患者出现与药物有关的不良反应现象。结论：对于复合小梁切除术后眼压波动于30 mm Hg以内的眼压控制不良患者，采用曲伏前列素滴眼液控制眼压，眼压基本能控制在16~18 mm Hg的安全范围内，能够有效避免视功能的进一步损害，保护患者的视力。%Objective:To observation of Travoprost therapy for patients with poor IOP control after trabeculectomy.Method:In the 13 cases of patients with glaucoma intraocular pressure bad control hospital compound trabeculectomy,the postoperative intraocular pressure control data were retrospectively analyzed, in 13 patients with intraocular pressure in the eye drop control winding forefront,if patients remain poorly controlled,the combined use of Brinzolamide Eye Drops control intraocular pressure,comparison and analysis of these 13 patients before treatment and after first,3,6,12 months,visual acuity,intraocular pressure, vision cup disc ratio and OCT optic nerve fiber thickness variation. Result:9 cases in the Travoprost Eye Drops IOP after treatment as well as the diurnal intraocular pressure difference control in the normal range,the effective rate of treatment was 69.2%;in the visual field defect in 13 cases,visual field defect patients showed no deterioration;during follow-up 13 patients vision without falling,without increasing the cup to disc ratio,the optic nerve fiber without further thinning medication period,no adverse reactions were seen in 1 patients and drug related. Conclusion:The compound trabeculectomy intraocular pressure IOP in patients with poorly controlled within 30 mm Hg,the IOP hormone eye drops in the forefront of control,intraocular pressure can be controlled in 16-18 mm Hg of the safe range,to avoid further damage of visual function,protect patients visual acuity.