金属内支架置入与联合放疗治疗中晚期食管癌的临床观察

摘要

Objective:To observe the clinical effect of metal stent implantation combined with radiotherapy for treatment of middle-advanced stage esophageal cancer and discuss its possible application prospect.Method:120 patients with middle-advanced stage esophageal cancer were chosen and randomly divided into two groups,both with 60 cases. Experiment group was given metal stent implantation combined radiotherapy for treatment and control group was only given metal stent implantation for treatment. Curative effects and adverse reactions of the two groups were compared.Result:After treatment course,total effective rate of experiment group was 95.00%while control group was 78.33%(P<0.05);3 cases(5.00%) of myelosuppression,5 cases(8.33%) of gastrointestinal reactions and 1 case(1.67%) of fluster occurred in experiment group. Conclusion:Metal stent implantation combined radiotherapy has a better clinical effect than pure metal stent implantation for treatment of middle-advanced stage esophageal cancer and it has few side effects and good clinical safety. It can improve life qualities of patients with middle-advanced stage esophageal cancer,so it is worth of further study and popularization.%目的：观察金属内支架置入与联合放疗治疗中晚期食管癌的临床疗效，探讨其可能的应用前景。方法：选取2011年3月-2013年5月来笔者所在医院肿瘤科住院治疗的中晚期食管癌患者120例，随机分为试验组和对照组，各60例，试验组给予金属内支架置入与联合放疗治疗，对照组仅给予金属内支架置入治疗，比较两组治疗效果及不良反应情况。结果：疗程结束后，试验组总有效率为95.00%，对照组总有效率为78.33%，差异有统计学意义(P<0.05)；试验组出现骨髓抑制3例，占5.00%，胃肠道反应5例，占8.33%，心悸1例，占1.67%。结论：应用金属内支架置入与联合放疗治疗中晚期食管癌的疗效较单纯应用金属内支架置入治疗更显著，并且副作用不大，临床安全性较好，能够提高中晚期食管癌患者的生活质量，值得进一步的研究和推广。