巨噬细胞炎性因子与肾脏疾病的相关性研究进展

摘要

巨噬细胞炎性因子(macrophage inflammatory protein-1α，MIP-1α)在调控免疫细胞到达受损组织过程中发挥着重要作用，是近年来研究较广泛的一种趋化因子。它隶属于趋化因子中的CC亚家族，可介导各个系统炎症反应的发展，包括呼吸、神经、泌尿、消化、血液及免疫等系统，同时还与肿瘤的发生密切相关，其表达于炎症反应的不同阶段，因此，MIP-1α在各类炎症反应中的表达引起医学界的广泛关注。%Macrophage inflammatory factor(MIP-1α) plays an important role in the regulation of immune cells to damaged tissue process,is more extensive research in recent years as a chemokine.It belongs to the CC chemokine subfamily,mediates the development of inflammation in various systems,including respiratory,nervous,urinary,digestive,circulatory and immune systems,also closely associated with tumors,and its expression in inflammation different stages of reaction,therefore,MIP-1αexpression in various types of inflammation caused widespread concern in the medical profession.