Objective:To observe the cerebral white matter structure changes in patients with vascular dementia(VD)by DTI. Methods:25 cases of vascular dementia patients and 25 healthy volunteers were selected,they were checked by 1.5 TMRI,the anisotropic fraction(FA)and apparent diffusion coefficient(ADC)values were measured in the same region of interest(ROI)after conventional MRI and DTI scanning,then we made a comparison.Results:The FA values of prefrontal brain white matter,genu and splenium of corpus callosum of the VD group decreased,ADC values increased,compared with the NC and the AD groups,the differences were statistically significant(P<0.05).Conclusion:DTI can be used in the evaluation of cerebral white matter damage in patients with dementia,compared with the traditional MRI,DTI can provide a more objective method to identify patients with VD.%目的：使用DTI观察血管性痴呆(VD)患者脑白质微结构的改变。方法：选择血管性痴呆患者及健康志愿者各25例，使用1.5 TMRI检查，采用常规MRI和DTI扫描后，测定相同感兴趣区(ROI)的各向异性分数(FA)值和表观扩散系数(ADC)值，进行比较。结果：VD 组前额叶脑白质、胼胝体膝部、胼胝体压部 FA 值下降，ADC 值升高，与NC、AD 组比较，差异有统计学意义(P＜0.05)。结论：DTI 能用于评价痴呆患者脑白质微结构损害，相对于传统MRI，DTI能提供更加客观的方法来鉴别诊断VD患者。
展开▼
