首发吸烟精神分裂症患者血清神经元特异性烯醇化酶、认知功能及临床特征研究

摘要

目的：对首发吸烟精神分裂症患者血清神经元特异性烯醇化酶(NSE)、认知功能及临床特征进行分析研究。方法：收治首发吸烟精神分裂症患者70例，用阳性和阴性症状量表(PANSS)与临床疗效总评量表(CGI)评定临床症状特征、用威斯星卡片分类测验(WCST)评测认知功能，用化学发光法检测血清NSE水平。结果：吸烟患者血清NSE水平高于非吸烟患者，差异具有统计学意义(P＜0.05)。结论：吸烟可能是精神分裂症的环境易感染因素之一。%Objective:To investigate and analyze the serum neuron-specific enolase,cognitive function and clinical characteristics of first episode schizophrenia who are smoking.Methods:70 patients with first episode schizophrenia who are smoking were selected,we evaluated the patients' clinical symptom characteristics with positive and negative symptoms scale(PANSS)and the clinical global impression scale (CGI),with Wes Star Card Sorting Test(WCST)to evaluate the cognitive function of patients, detected Serum NSE level by chemiluminescence method.Results:The serum NSE level in patients with smoking was higher than that in non smoking patients,the difference was statistically significant(P<0.05).Conclusion:Smoking may be one of the factors in environment susceptible of schizophrenia.