食管癌患者外周血清中P53表达水平及临床意义

摘要

Objective:To measure the serum P53 protein content of patients with esophageal cancer,to analyze its clinical significance.Methods:86 patients with esophageal disease were selected from September 2010 to August 2014.According to the pathological diagnosis result,the patients were divided into the esophagitis group and the esophageal cancer group.The serum P53 protein contents of two groups were measured,the difference of two groups was analyzed.The esophageal cancer group was given comprehensive treatment,after 2 months,the serum P53 protein content was counterchecked,the differences between before and after treatment were analyzed.The clinical significance of serum P53 protein content in the esophageal cancer group was analyzed under combined with clinical pathological characteristics.Results:P53 protein content in the peripheral serum:the esophagitis group was (0.726 ± 0.531)μg/mL,the esophageal cancer group before treatment was (2.381 ± 1.412)μg/mL,after treatment was (1.096 ± 0.689)μg/mL.The two groups comparison had statistical significant difference.Before and after treatment of esophageal cancer were compared with statistical significant difference(P<0.05).The serum P53 protein content of patients with esophageal carcinoma had correlation with cell differentiation,local infiltration, lymph node metastasis.Conclusion:The serum P53 protein content of patients with esophagus cancer has certain guiding significance for diagnosis and prognosis of esophagus cancer.%目的：测定食管癌患者血清中P53蛋白含量，分析其临床意义。方法：2010年9月-2014年8月收治食管疾病患者86例，根据病理组织学诊断结果，分为食管炎组和食管癌组，测定两组血清中P53蛋白含量，对比分析两组的差异性。食管癌组给予综合治疗2个月后，复查血清中P53蛋白含量，对比分析治疗前后的差异性。结合临床病理特征分析食管癌组血清中P53蛋白含量的临床意义。结果：外周血清中P53蛋白含量，食管炎组(0.726±0.531)μg/mL，食管癌组治疗前(2.381±1.412)μg/mL，治疗后(1.096±0.689)μg/mL。两组对比差异有统计学意义。食管癌治疗前后对比差异有统计学意义(P＜0.05)。食管癌患者血清中P53蛋白含量与细胞分化、局部浸润、淋巴结转移相关。结论：食管癌患者血清中P53蛋白含量对食管癌的诊断及预后有一定的指导意义。