促性腺激素治疗男性低促性腺激素性性腺功能减退症的疗效评估

摘要

目的：观察应用促性腺激素治疗男性低促性腺激素性性腺功能减退症的疗效。方法：将低促性腺激素性性腺功能减退症患者66例随机分为对照组与试验组。对照组采用 HCG 1500 IU 肌肉注射，每周2次，试验组采用HCG 1500 IU+HMG 75 IU 联合肌内注射，每周2次，比较两组治疗效果。结果：治疗前睾丸体积(3.08±2.44)mL，治疗后(8.92±5.37)mL，试验组和对照组治疗前后睾丸体积差异具有统计学意义(P＜0.01)。患者血清卵泡刺激素、黄体生成素和睾酮平均水平提高。结论：HCG和HMG治疗能促进男性低促性腺激素性性腺功能减退症患者青春期第二性征发育，外生殖器和睾丸进一步发育，并可部分恢复睾丸产生雄激素和生成精子的功能，明显优于以往单纯使用或者过早使用雄激素替代的治疗方案。%Objective:To observe the curative effect of gonadotropins in the treatment of male lower hypogonadotropic hypogonadism.Methods:66 cases of patients with lower hypogonadotropic hypogonadism were randomly divided into the control group and the experimental group.The control group adopts intramuscular HCG 1500 IU,2 times per week,and the experimental group adopts intramuscular HCG 1500 IU joint HMG 75 IU,2 times per week.We compared the therapeutic effect of the two groups.Results:The testicular volume was (3.08±2.44)mL before the treatment and (8.92±5.37)mL after the treatment,and there were statistical significant differences of testicular volume in the experimental group and the control group before and after the treatment(P<0.01).The average serum follicle-stimulating hormone,luteinizing hormone and testosterone in patients increased. Conclusion:HCG and HMG therapy could improve the adolescent of secondary development with lower male lower hypogonadotropic hypogonadism and external genital organs and testicular could develop further and can restore the two function of testicular androgen and sperm generation,which was much better than before or early androgen replacement therapy alone.