半夏泻心汤用于功能性消化不良患者中的疗效及预防复发作用

摘要

目的：探讨半夏泻心汤用于功能性消化不良(FD)患者中的疗效及预防复发作用。方法：2011年4月-2013年10月收治FD患者74例，随机分为中药组和对照组各37例。对照组予以莫沙必利胶囊5 mg/次，3次/d。中药组予以半夏泻心汤治疗，1剂/d。治疗6周后观察两组临床效果及不良反应，并随访半年比较其复发率。结果：治疗6周后，中药组临床总有效率(94.59%)明显优于对照组(75.68%)(χ2=5.23，P＜0.05)。中药组治疗中出现不良反应3例，对照组出现6例，症状均较轻微，两组比较差异不明显(χ2=0.51，P＞0.05)。随访观察半年中药组复发率(20.00%)明显低于对照组(42.86%)(χ2=3.86，P＜0.05)。结论：半夏泻心汤用于FD患者治疗效果明显优于莫沙必利，能更明显改善其消化不良症状，安全性较佳，能明显降低其复发率。%Objective:To explore the curative effect and recurrence prevention of Banxiaxiexin decoction in the treatment of the patients with functional dyspepsia.Methods:74 cases of patients with FD from April 2011 to October 2013 were randomly divided into the Chinese medicine group and the control group(with 37 cases in each group).The control group were treated with mosapride citrate capsules 5 mg/time,3 times/d.The chinese medicine group were treated with Banxiaxiexin decoction,1 time/d.6 weeks after the treatment,the clinical effect and adverse reaction in both groups were observed,and the recurrences were compared follow-up of six months.Results:6 weeks after the treatment,the clinical total effective rate of the Chinese medicine group(94.59% )was obviously better than that of the control group(75.68%)(χ 2=5.23,P<0.05).3 cases had adverse reactions in Chinese medicine group and 6 cases had adverse reactions in the control group,the symptoms are mild,there was no obvious difference(χ 2=0.51, P>0.05).Follow-up for half one year,the recurrence rate of the Chinese medicine group(20.00%) was obviously lower than that of the control group(42.86%)(χ2=3.86,P<0.05).Conclusion:Banxiaxiexin decoction in the treatment of patients with FD had better effect than mosapride citrate,which could improve the symptoms of indigestion more obviously and had better security and reduce the recurrence rate.