儿童静脉注射丙种球蛋白治疗不敏感川崎病16例的临床特点及效果分析

摘要

目的：探讨丙种球蛋白不敏感川崎病的临床特点及治疗效果。方法：收治216例川崎病患儿，其中对丙种球蛋白不敏感16例，分析其临床特点及治疗效果。结果：敏感组和不敏感组在血沉、乳酸脱氢酶、C反应蛋白、血红蛋白、白细胞总数方面比较，差异无统计学意义(P＞0.05)，而在白蛋白指标方面比较，差异有统计学意义(P＜0.05)，经过治疗，白细胞总数、C反应蛋白和血沉明显降低(P＜0.05)，血红蛋白和血细胞比容变化，差异无统计学意义(P＞0.05)。结论：男性患儿发病率较高，冠状动脉病变发生率高是丙种球蛋白不敏感川崎病的临床特点，阿司匹林联合丙种球蛋白治疗疗效确切。%Objective:To explore the clinical characteristics and effect of Kawasaki disease with insensitivity for intravenous injection gamma globulin.Methods:216 cases of children with Kawasaki disease were selected.Among them,16 cases was not sensitive for gamma globulin.We analyzed the clinical characteristics and treatment effect.Results:In the sensitive group and the non sensitive group,there were no statistically significant differences in the erythrocyte sedimentation rate,lactate dehydrogenase, C reaction protein,hemoglobin and total number of white blood cells(P>0.05),but there was significant difference in albumin index(P<0.05).After treatment,the total number of white blood cells,C reactive protein and erythrocyte sedimentation rate were significantly decreased(P<0.05),and there were no significant differences in hemoglobin and hematocrit changes(P>0.05). Conclusion:The incidence of males was higher,the high incidence of coronary artery disease was a clinical feature of Kawasaki disease with insensitivity for intravenous injection gamma globulin.The curative effect of aspirin combined with gamma globulin was exact.