孕晚期注射乙肝免疫球蛋白对乙肝病毒母婴传播的阻断效果

摘要

Objective:To explore the blocking effect of hepatitis B immunoglobulin injected at late pregnancy for mother to child transmission of hepatitis B virus.Methods:150 cases of pregnant women were selected.The serum HBsAg and HBeAg of all pregnant women were positive.They were divided into the control group with 76 cases and the observation group with 74 cases.The pregnant women in the observation group during pregnancy were given hepatitis B immunoglobulin by injection.The pregnant women in the control group were not given hepatitis B immunoglobulin intervention.We compared the effect between groups. Results:At 6 months of birth,the HBsAg positive rate of the observation group of 2.6% was lower than 23% of the control group;the positive rate of HBsAb in the observation group of 44.7% was higher than 33.8% in the control group;the differences were statistically significant(P<0.05).At 12 months of birth,the HBsAg positive rate of the observation group of 2.6% was lower than 20.3% of the control group;the positive rate of HBsAb in the observation group of 55.3% was higher than 39.2% in the control group;the differences were statistically significant(P<0.05).Conclusion:Hepatitis B immunoglobulin injected at late pregnancy can effectively block the intrauterine infection.It may be an effective measure to be vaccinated with hepatitis B vaccine among women of childbearing age.%目的：探讨孕晚期注射乙肝免疫球蛋白对乙肝病毒母婴传播的阻断效果。方法：收治孕妇150例，孕妇血清HBsAg和HBeAg均阳性，分为对照组76例和观察组74例，观察组孕妇妊娠期间注射乙肝免疫球蛋白，对照组孕妇未进行乙肝免疫球蛋白干预，比较两组的效果。结果：出生6个月时，观察组HBsAg阳性率2.6%，低于对照组的23.0%；观察组HBsAb阳性率44.7%，高于对照组的33.8%；差异均有统计学意义(P＜0.05)。出生12个月时，观察组HBsAg阳性率2.6%，低于对照组的20.3%；观察组HBsAb阳性率55.3%，高于对照组的39.2%；差异均有统计学意义(P＜0.05)。结论：孕晚期注射乙肝免疫球蛋白可有效阻断宫内感染。对育龄前女性普遍接种乙肝疫苗可能是一个有效措施。