多形性黄色星形细胞瘤的影像学和临床病理分析

摘要

目的：探讨多形性黄色星形细胞瘤(PXA)的影像学和病理学特征。方法：收治PXA患者5例，对其进行MRI及病理学检查。结果：MRI检查表明左侧海马斑片状出现直径1.0 cm左右的异常信号影。患者病灶区可以观察到血管周淋巴细胞浸润，但是并没有观察到血管内皮细胞增生、病理性核分裂以及坏死。免疫组化示CD163、NF、EMA以及NeuN等染色结果呈阴性。结论：PXA是一种比较罕见的致病性星形细胞瘤，如果手术可以彻底、完整地切除，一般患者预后比较良好，然而具有间质特征的原发性PXA以及恶性转化的PXA等高级别胶质瘤患者的预后通常比较差。%Objective:To investigate the pathogenesis,clinical pathological characteristics,diagnosis,treatment and prognosis on patients with pleomorphic xanthoastrocytoma.Methods:5 patients with PXA were selcted,then they were given imaging and immunohistochemistry examination.Results: MRI showed signal shadow of 1.0 cm in diameter in the left hippocampal patchy appear abnormal.Vascular lesion area can be observed in patients with weeks lymphocyte infiltration, but vascular endothelial cell proliferation, pathological karyokinesis and necrosis were not observed.The immunohistochemical staining showed that CD163,NF, EMA and NeuN were negative.Conclusion:PXA is a rare disease of pathogenic star cell tumor.If the surgery can resection it completely,the prognosis is good,but the prognosis on primary PXA with interstitial features and malignant transformation of PXA and other high grade gliomas are generally poor.