度洛西汀与帕罗西汀治疗老年抑郁症患者的效果研究

摘要

Objective:To explore the efficacy of duloxetine and paroxetine in the treatment of depression in elderly patients. Methods:90 elderly patients with depression were selected.They were randomly divided into the A group and the B group.The A group was treated with duloxetine.The B group was treated with paroxetine.We compared the treatment effect of two groups. Results:There was no significant difference in total effective rate between groups(P>0.05).After treatment for 1 to 2 weeks,the HAMD sleep disorder factor and PSQI in the A group were significantly lower than those in the B group(P<0.05).After 4 weeks of treatment,there was no significant difference between groups(P>0.05).Conclusion:Duloxetine and paroxetine can get significant effect in the treatment of senile depression,duloxetine worked faster,and early subjective sleep quality improvement was superior to paroxetine.%目的：探讨度洛西汀与帕罗西汀治疗老年抑郁症的效果。方法：收治老年抑郁症患者90例，随机分成A组和B组，A组采用度洛西汀治疗，B组采用帕罗西汀治疗，比较两组治疗效果。结果：两组总有效率比较，差异无统计学意义(P＞0.05)。治疗1～2周后，A组患者HAMD睡眠障碍因子、PSQI 评分明显低于B组(P＜0.05)；治疗4周后两组数据比较，差异无统计学意义(P＞0.05)。结论：度洛西汀与帕罗西汀治疗老年抑郁症均可获得显著效果，度洛西汀起效更快，早期患者主观睡眠质量改善情况优于帕罗西汀。