Objective To evaluate the clinical significance of quantitative determination of PET/CT standardized uptake value (SUV) and serum lactic dehydrogenase (LDH) in patients with non-Hodgkin's lymphoma (NHL),and to explore the relationship between them. Methods Data of the 45 patients from 2007 to 2009 were retrospectively analyzed. Relationship of SUV and LDH with age,group,tumor staging,bone marrow involvement,Ki-67 and grade malignancy was observed. Results The levels of LDH in stage,B group,bone marrow involvement, high Ki-67 and malignancy were obviously higher than their comparison counterpart and the difference was significant (P ＜0. 05). But the levels of SUV only in the high Ki-67 and malignancy were obviously higher than their comparison counterpart. A receiver operating characteristic (ROC) analysis demonstrated that the SUV distinguished reasonably well between aggressive and indolent disease (area under ROC curve, 0. 911 ), and so do LDH( area under ROC curve, 0. 811 ). Conclusion LDH has sisnificant value in the treatment directing and prognosis assessing of malignant lymphomal, and SUV is significantly correlated with LDH.%目的 探讨18F-FDG PET/CT的标准摄取值(SUV)和血清乳酸脱氢酶(LDH)在非霍奇金淋巴瘤(NHL)中的相关因素及二者的相关性.方法 分析45例初治NHL患者SUV、LDH与年龄、分期、B症状、骨髓浸润、Ki-67表达、恶性程度之间的关系及二者的相关性.结果 LDH与分期、B症状、骨髓浸润、Ki-67阳性率、恶性程度密切相关(P＜0.05),而与年龄无关(P＞0.05).SUV与Ki-67阳性率(P=0.011)、恶性程度(P=0.001)均相关.受试者工作曲线结果提示SUV、LDH能够较准确地反映NHL的侵袭性,曲线下面积分别为0.911和0.811.SUV与LDH呈正相关(r=0.400,P＜0.05).结论 LDH与NHL的分期、B症状、骨髓浸润、Ki-67阳性率、恶性程度密切相关,而SUV与Ki-67阳性率、恶性程度有关,SUV和LDH亦呈正相关.LDH与SUV均可作为NHL恶性程度的参考指标.
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