P-钙粘蛋白在乳腺癌组织中的表达及临床意义

摘要

目的 探讨乳腺癌组织中P-钙粘蛋白(P-cadherin)的表达及其与临床病理特征的关系.方法 采用免疫组化SP法检测106例乳腺癌组织及30例癌旁组织中P-cadherin的表达,分析其表达与乳腺癌患者的年龄、肿瘤大小、组织学分级、TNM分期、淋巴结转移、HER-2、ER和PR的关系.结果 乳腺癌和癌旁组织中P-cadherin的阳性表达率分别为42.5％(45/106)和13.3％ (4/30),差异有统计学意义(P＜0.05)；P-cadherin表达与乳腺癌TNM分期、组织学分级、淋巴结转移、HER-2、ER和PR有关(P＜0.05),而与年龄及肿瘤大小无关(P＞0.05).结论 P-cadherin在乳腺癌组织中高表达,并可能与乳腺癌的恶性程度及不良预后有关.%Objective To investigate the expression of P-cadherin in breast cancer,and analyze its relationship with clinicopathological characteristics.Methods The expression of P-cadherin in 106 cases of breast cancer specimens and 30 adjacent normal tissues were detected by immunohistochemical method(SP),and the relationship between its expression and clinical characteristics were analyzed.Results The positive expression rates of P-cadherin in breast cancer and adjacent normal tissue were 42.5％ and 13.3％ respectively,and the difference was statistically significant (P ＜ 0.05).P-cadherin expression in breast cancer was correlated with TNM stage,histological grade,lymph node metastasis,HER-2 situation,ER and PR(P ＜ 0.05),but not correlated with age and tumor size(P ＞ 0.05).Conclusion The over-expression of P-cadherin in breast cancer may relate to the level of malignancy and poor prognosis.