重组人粒细胞集落刺激因子混合液治疗化疗引起口腔溃疡的临床观察

摘要

Objective To investigate the clinical efficacy of recombinant human granulocyte colony⁃stimulating factor ( rhG⁃CSF) collutory on chemotherapy⁃induced oral ulcer. Methods Fifty cases of malignant tumors patients were divided into control group and observation group with 25 cases in each group according to random number table.The control group was treated by Bingpeng pow⁃der,Xilei powder plus 100 ml normal saline with gargling administration(10 ml each time, 3⁃5 times daily, 3 min for each gargling) and the observation group was treated by mouthwash containing 100 ml normal saline, rhG⁃CSF 100 μg, dexa⁃methasone 5 mg, lido⁃caine 10 ml,gentamicin 160 thousand unit, Bingpeng powder and Xilei powder with the same usage and dosage of control group. Two groups were given mouthwash from the occurrence of oral ulcer within 24 hours until oral ulcer healing or completing 7 days of mouth rinse. The overall response rate of oral ulcer healing, remission rate of pain, the time of alleviating pain and the average healing time of oral ulcer were observed and recorded. Results In observation group, the response rate of oral ulcer healing was 92�0%, while in control group it was only 60�0% with statistic significance( P<0�05) . The pain remission rate of observation group was 84�0%,which was significantly superior to that of the control group(52�0%) with significant difference(P<0�05). After treatment, the pain scores (VAS) of observation group improved more than that of control group at different time points(P<0�05).The average healing time of o⁃ral ulcer in observation group was significantly shorter than that of control group[(3�5±1�2) d vs.(5�7±1�3) d,P<0�05]. Conclu⁃sion The efficacy of rhG⁃CSF collutory on treating chemotherapy⁃induced oral ulcer is satisfactory. It can effectively reduce the severi⁃ties of oral pain and the time of alleviating pain,improve oral ulcer healing,and obviously shorten the healing time of oral ulcer.%目的：观察重组人粒细胞集落刺激因子（ rhG⁃CSF）混合液治疗恶性肿瘤化疗引起口腔溃疡的临床效果。方法将50例恶性肿瘤患者按数字表法随机分为观察组和对照组，每组25例。对照组采用0�9％氯化钠注射液100 ml加冰硼散3 g、锡类散1 g配制的含漱液。观察组为在对照组基础上加入rhG⁃CSF 100μg、庆大霉素16万U、地塞米松5 mg及2％利多卡因10 ml配制的含漱液。两组患者均予10 ml／次含漱，每日3～5次，每次3 min；从发生口腔溃疡24 h内开始用药，至口腔溃疡愈合或治疗7d后停药。观察并记录两组患者口腔溃疡的治疗有效率、疼痛缓解率、疼痛缓解时间及溃疡愈合时间。结果观察组口腔溃疡的治疗有效率为92�0％，高于对照组的60�0％（ P＜0�05）；观察组的疼痛缓解率优于对照组（84�0％ vs．52�0％），差异有统计学意义（ P＜0�05）；给药后观察组不同时间点的口腔溃疡疼痛评分均显著低于对照组（ P＜0�05）；观察组的口腔溃疡平均愈合时间明显短于对照组[（3�5±1�2） d vs．（5�7±1�3） d，P＜0�05]。结论 rhG⁃CSF混合液含漱治疗化疗后引起的口腔溃疡效果显著，能有效减轻患者的疼痛程度和时间，加快创面愈合，明显缩短口腔溃疡的愈合时间。