MEDICAMENT FOR LOCALLY TREATING OR PREVENTING A CHEMOTHERAPY-INDUCED MUCOSITIS AND OTHER SIDE EFFECTS RESULTING FROM CHEMOTHERAPY

摘要

The invention relates to a medicament for locally treating or preventing a mucositis, which is induced by chemotherapy with thymidylate synthase inhibitors, in the oral cavity and in the gastrointestinal tract, whereby a thymidylate synthase mutant, which is coupled to a transductor for the transduction into a cell, which has an intact enzyme activity, and which is resistant to thymidylate synthase inhibitors, is administered.